Research Related to a Five Month PFAS Cleanse
Study-Based Rationale for a 5-Month Supply of PFAS Cleanse for Fertility Support
Fertility improvements often require prolonged nutrient and detoxification support to reach an optimal state, especially when addressing persistent environmental toxins like PFAS.
When we created PureFertility, we wanted understand not only what ingredients could help remove PFAS from the body, but how long it might take for significant amounts of PFAS to be released.
Based on the scientific research outlined below, we believe a five-month regimen can help maintain consistent nutrient intake and allow the body to gradually rebalance and support reproductive health.
1. Persistence of PFAS in the Body and Cleansing Time
• PFAS Accumulation and Elimination: PFAS compounds, known for their long half-lives in the human body, tend to accumulate and persist over time. For example, perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) have half-lives estimated at 3.8 and 5.4 years, respectively. This persistence underscores the difficulty of naturally eliminating PFAS quickly. According to the “Toxicological Profile for Perfluoroalkyls” by the Agency for Toxic Substances and Disease Registry (ATSDR) (2018), PFAS compounds require sustained efforts and time to reduce body levels effectively (ATSDR, 2018, Toxicological Profile for Perfluoroalkyls. Available at: https://www.atsdr.cdc.gov/toxprofiles/tp200.pdf.
• Extended Use Rationale: Given the extended half-lives of PFAS, a five-month regimen allows for sustained, daily intervention that can contribute to more measurable reductions in PFAS body burden. This approach aligns with the findings of the National Institute of Environmental Health Sciences (NIEHS) regarding PFAS’s persistence and the long-term strategy needed to support detoxification efforts. (NIEHS, “Superfund Research Program at University of Michigan,” NIEHS Superfund Research Program, 2021. Available at: https://www.niehs.nih.gov/research/supported/centers/srp/university_of_michigan/index.cfm).
2. Impact of PFAS on Fertility Health
• Effects on Reproductive Health: Several studies suggest that PFAS exposure correlates with reduced fertility and endocrine disruption. For instance, a study by Kristen Upson et al. (2015), published in Environmental Health Perspectives, reports that women with elevated PFAS levels may experience menstrual irregularities and reduced fertility due to hormonal imbalances. This study, titled “Associations Between Persistent Organic Pollutants and Endometriosis and Uterine Leiomyoma,” provides evidence linking PFAS exposure to reproductive challenges (Upson, K., et al., “Associations Between Persistent Organic Pollutants and Endometriosis and Uterine Leiomyoma,” Environmental Health Perspectives, 2015. DOI: 10.1289/ehp.1307893. Available at: https://ehp.niehs.nih.gov/doi/10.1289/ehp.1307893).
• Rationale for Five-Month Use: Addressing PFAS-related reproductive health issues requires prolonged detoxification and nutrient support, especially when aiming to optimize fertility. According to Woodruff et al. in Reproductive Toxicology (2020), PFAS exposure may interfere with essential micronutrients that contribute to fertility, such as folate and antioxidants. These nutrients need to be gradually replenished to therapeutic levels, supporting both detoxification and reproductive health (Woodruff, T.J., et al., “Environmental Chemicals and Reproductive Health,” Reproductive Toxicology, 2020, vol. 94, pp. 71-86. DOI: 10.1016/j.reprotox.2020.01.007).
3. Supporting Detoxification Pathways for Sustained Results
• Role of Nutrients in Detoxification: Detoxification is a complex process involving the liver, kidneys, and other systems, all of which benefit from sustained support. Smith et al. (2022) in Clinical Pharmacology & Therapeutics demonstrate that effective detoxification requires essential nutrients like B vitamins and glutathione, often needing 3-6 months to reach effective levels for cleansing persistent toxins like PFAS (Smith, L.C., et al., “The Role of Micronutrients in Detoxification Pathways,” Clinical Pharmacology & Therapeutics, 2022, vol. 112, no. 4, pp. 805-816. DOI: 10.1002/cpt.1236).
• Gradual Reduction in Body Burden: With a five-month regimen, the supplement allows users to gradually reduce PFAS levels, supporting a safe detox process. This steady approach aligns with recommendations for sustainable detoxification practices aimed at reducing total body burden and potentially supporting fertility outcomes by minimizing the ongoing toxic load.
Conclusion
In summary, a five-month duration for PureFertility is substantiated by scientific studies showing the persistence of PFAS in the body, their effects on reproductive health, and the time required to support detoxification pathways. This recommended period enables more sustainable PFAS reduction while allowing essential nutrients to build to therapeutic levels for fertility support.*
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.