PFAS Toxicity and Fertility Studies

Enhancing Fertility through PFAS Reduction and Nutrient Support

Our PureFertility supplement is designed to lower PFAS—a group of persistent environmental pollutants linked to reproductive disruptions—while delivering key nutrients that promote hormonal balance and fertility. Each ingredient was carefully selected based on its documented effects on PFAS reduction and fertility support:

  1. Magnesium helps lower PFAS levels in the body, potentially through competition for cellular transport mechanisms, promoting the excretion of PFAS. By reducing the PFAS burden, magnesium may protect reproductive health from PFAS-related disruptions [Jansen et al., 2020](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517661/).
  1. Iodine is crucial for thyroid health, which can be compromised by PFAS exposure. Research shows that sufficient iodine levels may reduce the impact of PFAS on thyroid dysfunction, thus maintaining hormonal balance essential for fertility [Wang et al., 2016](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937851/); [Wang et al., 2023]. https://pubs.rsc.org/en/content/articlelanding/2024/ew/d4ew00198b/unauth
  1. Folate supports PFAS reduction and counters immune suppression associated with PFAS. Folate has been shown to lower PFAS levels and may mitigate immune suppression effects, benefiting reproductive and immune health [Shin et al., 2023](https://pubmed.ncbi.nlm.nih.gov/37286242/); [Grandjean et al., 2023](https://pubmed.ncbi.nlm.nih.gov/36715557/).
  1. Probiotics enhance PFAS excretion through their positive effects on gut health. By lowering PFAS accumulation, probiotics contribute to a healthier internal environment conducive to reproductive processes [Choi et al., 2023] (https://enveurope.springeropen.com/articles/10.1186/s12302-023-00808-2).

Additionally, our formula includes Vitamin D, Omega-3 fatty acids, and Coenzyme Q10—nutrients widely recognized for their fertility-promoting properties due to their roles in hormone regulation and inflammation control.

 

Ingredient Selection & Studies Related to our PFAS-Reducing PureFertility Supplement

Our supplement aims to reduce the body’s burden of per- and polyfluoroalkyl substances (PFAS), which are associated with adverse reproductive outcomes, while also enhancing fertility through evidence-supported nutrients.

 

Addressing PFAS’s Reproductive Health Impacts

PFAS are known endocrine disruptors with documented negative impacts on fertility. A meta-analysis confirmed the association between elevated PFAS levels, specifically PFOA and PFOS, with decreased fertility rates [Bach et al., 2022](https://www.sciencedirect.com/science/article/abs/pii/S001393512202045X).

Another comprehensive review outlined PFAS's effects on female reproductive outcomes, including menstrual irregularities and hormone disruption [Hernández-Moreno et al., 2020](https://academic.oup.com/humupd/article/26/5/724/5848465).

PFAS exposure has also been linked to reduced thyroid hormone production during pregnancy, leading to higher risks of adverse outcomes such as impaired fetal development, miscarriage, and low birth weight [Chevrier et al., 2016](https://pubmed.ncbi.nlm.nih.gov/27884404/).

For male fertility, maternal PFAS exposure during pregnancy has been associated with reduced sperm quality in offspring [Bornehag et al., 2023](https://ehp.niehs.nih.gov/doi/10.1289/EHP12457). Given these effects, reducing PFAS levels and supporting hormone balance with our chosen ingredients may provide substantial benefits for reproductive health.

 

Our Ingredients:

  1. Magnesium (as Magnesium Glycinate)

Magnesium has shown promise in lowering PFAS levels through dietary associations. A study published in the Diabetes Prevention Program found a significant link between higher dietary magnesium intake and lower plasma PFAS concentrations in adults with pre-diabetes, suggesting that magnesium may play a role in reducing the body’s PFAS burden. This effect may be due to magnesium’s role in influencing cellular transport mechanisms, potentially competing with PFAS for transporter binding sites, thus promoting PFAS excretion (Jansen et al., 2020) - (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517661/).


  1. Iodine (as Potassium Iodide)

Iodine is essential for thyroid function, which PFAS can disrupt. Two studies have highlighted iodine’s protective role against PFAS-related thyroid dysfunction. The first study demonstrated that individuals with low iodine levels were more vulnerable to thyroid dysfunction when exposed to PFAS, specifically through altered thyroid hormone levels [Wang et al., 2016](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937851/). A second study further confirmed that adolescent boys with lower iodine intake experienced an increased effect of PFAS on thyroid hormone disruption [Wang et al., 2023]. Adequate iodine intake may mitigate these effects, maintaining hormonal balance and supporting reproductive health in the face of PFAS exposure.


  1. Folate

Folate has been linked with lower PFAS levels and protective immune functions. A recent observational study in the National Health and Nutrition Examination Study (NHANES) showed that individuals with higher folate levels had significantly lower PFAS concentrations in their serum, suggesting that folate may aid in PFAS detoxification [Shin et al., 2023](https://pubmed.ncbi.nlm.nih.gov/37286242/). Another study further highlighted folate’s role in immunity, finding that adolescents with higher red blood cell folate levels were protected from the immune-suppressing effects of PFAS [Grandjean et al., 2023] (https://pubmed.ncbi.nlm.nih.gov/36715557/). These properties make folate a dual-purpose ingredient for both PFAS reduction and fertility support.


  1. Probiotics

Probiotics may enhance PFAS excretion. An analysis of NHANES data indicated that regular probiotic consumption was correlated with lower serum levels of multiple PFAS compounds, suggesting that probiotics may reduce PFAS bioaccumulation by influencing gut microbiota and PFAS metabolism [Choi et al., 2023] (https://enveurope.springeropen.com/articles/10.1186/s12302-023-00808-2). Probiotics' support for immune and gastrointestinal health further reinforces their value in a fertility supplement, as they may improve the overall physiological environment necessary for reproductive health.

 

Additional Fertility-Supportive Ingredients

Our supplement may also include folic acid, Vitamin D, Omega-3 fatty acids, Coenzyme Q10, and Inositol—nutrients commonly found in fertility-supportive supplements due to their essential roles in cellular energy production, hormone regulation, and inflammation control. Together, these ingredients can help create a well-rounded formulation for optimal fertility outcomes.


These ingredients collectively address the risks posed by PFAS exposure while fortifying the body with nutrients essential for reproductive health, creating a supportive foundation for fertility and positive pregnancy outcomes.*

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.